"The Infallibility of the Prophets" is the basis of religious and verbal issues, which is the guarantee of the authenticity of the mission of the prophets and the celestial scriptures. In the Qur'an, the issue of "infallibility of the prophets" is referred to; and is considered one of the most essential interpretative issues. According to Shi'a, the Prophets, even before the creation, were innocent of the error and put forward a solid Qur'anic argument for their claim. Shiites believe in the infallibility of prophets at the time of their mission. Therefore, in this paper, with a comparative view of Shi'i commentators, the Qur'anic proofs, the proof of infallibility before the Prophet's believer was investigated. The result was that the Imāmī believe in the divine infallibility of the prophets, and prove the proof of infallibility to Species that include pre-existential periods. In the article of the verses which raised the doubt about the lack of infallibility of the Prophet Muhammad (PBUH) before his creation, according to the Shi'a view, a subject-comparative interpretation was investigated and infallibility was established before the Prophet's prophet (pbuh). In this way, the research method of the paper will be descriptive, analytical and subject-comparative interpretation.